Description
Product Characteristics:
Aliases: Arc 1 antibody, CADH1_HUMAN antibody, Cadherin 1 antibody, cadherin 1 type 1 E-cadherin antibody, Cadherin-1 antibody, Cadherin1 antibody, CAM 120/80 antibody, CD 324 antibody, CD324 antibody, CD324 antigen antibody, cdh1 antibody, CDHE antibody, E-Cad/CTF3 antibody, E-cadherin antibody, ECAD antibody, Epithelial cadherin antibody, epithelial calcium dependant adhesion protein antibody, LCAM antibody, Liver cell adhesion molecule antibody, UVO antibody, Uvomorulin antibody
Target Information: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]